When using a non-reflecting boundary condition, the solver crashes on the first iteration.
Release 10.0 SP1 introduced a bug in the CFX-Solver initializing the 'old nonreflecting pressure' (needed for the LODI equations) on the first timestep.
Running the CFX-Solver in double precision may help to resolve this problem.
Alternatively, do not install SP1 if you are using non-reflecting boundary conditions in you simulation. However, there are some improvements to this Boundary Condition type in Release 10.0 SP1, particularly for nonorthogonal elements at outflows.
Custom 10.0 executable available upon request.